cytoplasmic mRNA decay pathway

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Submitter: 
Leslie E. Sieburth
Description: 
My lab discovered a novel cytoplasmic mRNA decay pathway as the suppressor of decapping mutants, and we called the gene SUPPRESSOR OF VARICOSE. Since then the human homolog has been found to be active (called hDIS3L2), and mutations in hDIS3L2 have been linked to the human disease perlman syndrome.