circadian clock components


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Kevin M. Folta
To me, I think of circadian clock components that were relevant to the animal literature, that were found first in Arabidopsis. Even cry1 receptors are important in animals with a minor role in plants (at best). They were mentioned as a player in a 1999 review by Cashmore et al and I think spurred folks to check Drosophila.


Animal cry as a part of the clock system was first identified in Drosophila in 1998, independently of the identification of cry's as among the blue light photoreceptors that input to the Arabidopsis clock (also in 1998). The situation's complicated because in mammals cry is not a photoreceptor that alters the clock (as in fly and Arabidopsis) but rather a clock component. Also, the animal and plant cry's are not directly related, but both diverged from the photolyases.

However, one of the approaches in the fly was to identify a rhythm mutant, named cry-baby, in transgenic Drosophila that carried a rhythmic firefly luciferase reporter gene ( Real-time monitoring of luciferase in vivo, as a marker for dynamic gene expression, was pioneered in plants (tobacco then Arabidopsis but both published in 1992) , where we published the first clock mutants in 1995. The relevant Arabidopsis paper is Millar et al Plant Mol Biol. Reporter, doi: 10.1007/BF02668909