Encodes a telomeric DNA binding protein and Single Myb Histone (SMH) gene family member. In vitro, an N-terminal Myb domain enables it to interact with double-stranded telomeric repeats.Mutations in TRB1 and TRB3 enhance the lhp1 mutant phenotype. Triple mutants are more strongly affected than the respective double mutants with lhp1. TRB1 binds non-H3K27me3 target genes predominantly at the transcription start sites and its presence increases the expression of several of these targets, enriched for functions of primary metabolism. At H3K27me3 target genes, TRB1 binding is more distributed across gene bodies and at extended promoter regions, corresponding to an enrichment of putative binding sites "RMCCTAR". At these genes, TRB1 particiaptes in the repression because several direct targets are further upregulated in trb1 lhp1 double mutants as compared to lhp1 mutants.
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